He's DEPRESSED because he's pathetic
and creepy and can't get girls.
The Big Bang Theory Season 2, Episode 12
...because I'm fun,
I'm not clinically DEPRESSED at all.
The Big Bang Theory Season 6, Episode 5
Are you DEPRESSED because you're
alone and no one loves you?
The Big Bang Theory Season 4, Episode 5
Well, not so much DEPRESSED
as lonely.
The Big Bang Theory Season 4, Episode 22
It's Christmastime and
Jimmy Stewart's really DEPRESSED
The Big Bang Theory Season 7, Episode 11